CE is usually asymptomatic or presents with only subtle symptoms, including abnormal uterine bleeding, dyspareunia, leucorrhea, and pelvic pain. Twist family basic helix-loop-helix transcription factor 2Ĭhronic endometritis (CE) is a persistent chronic inflammatory process of the endometrium. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting information files.įunding: Grants-in-Aid for Scientific Research of Japan Society for the Promotion of Science, Grant Number 16K11083 and 19K09752 (to F.K.), supported this study regarding the design of the study and data collection, analysis, interpretation of data and in writing the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Received: OctoAccepted: MaPublished: April 7, 2021Ĭopyright: © 2021 Ishida et al. PLoS ONE 16(4):Įditor: Paola Viganò, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, ITALY (2021) Induction of the epithelial-mesenchymal transition in the endometrium by chronic endometritis in infertile patients. The association between variables, including age, body mass index, gravidity, parity, and each causative factor of infertility and epithelial-mesenchymal transition positivity was analyzed.Ĭitation: Ishida M, Takebayashi A, Kimura F, Nakamura A, Kitazawa J, Morimune A, et al. ![]() The characteristics of the patients in the epithelial-mesenchymal transition-positive and epithelial-mesenchymal transition-negative groups were compared. Epithelial-mesenchymal transition-positive cases were also statistically analyzed according to the presence of chronic endometritis. When the loss of E-cadherin expression and/or the positive expression of N-cadherin was detected, the specimen was considered epithelial-mesenchymal transition-positive. Immunohistochemical staining for E-cadherin, N-cadherin, Slug, and Snail was performed, and the expression profiles were statistically analyzed according to the presence of chronic endometritis. The presence of chronic endometritis was investigated by immunostaining for CD138. ![]() Endometrial biopsy specimens from 66 infertility patients were analyzed.
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